Table I.
Radiation-induced mutagen sensitivity status by select variables in glioma patients
| Variables | All cases (N = 426) |
Comparisona |
||||
| N (%)b | B/C mean (SD) | P-value | Non-sensitive (n = 223) | Sensitive (n = 203) | P-value | |
| Age, years | ||||||
| Mean | 44.9 | |||||
| Range | 18–78 | |||||
| ≤45 | 213 (50.0) | 0.66 (0.54) | 0.15 | 110 (49.3) | 103 (50.7) | 0.85 |
| >45 | 213 (50.0) | 0.59 (0.46) | 113 (50.7) | 100 (49.3) | ||
| Sex | ||||||
| Male | 267 (62.7) | 0.60 (0.45) | 0.30 | 148 (66.4) | 119 (58.6) | 0.08 |
| Female | 159 (37.3) | 0.66 (0.57) | 75 (33.7) | 84 (41.4) | ||
| Smoke | ||||||
| Ever | 186 (43.7) | 0.63 (0.51) | 0.91 | 96 (47.1) | 90 (48.9) | 0.72 |
| Never | 202 (47.4) | 0.62 (0.52) | 108 (52.9) | 94 (51.1) | ||
| First-degree family history of brain tumor | ||||||
| Yes | 13 (3.1) | 0.38 (0.13) | 0.16 | 10 (4.7) | 3 (1.6) | 0.07 |
| No | 394 (92.5) | 0.63 (0.49) | 205 (95.3) | 189 (98.4) | ||
| Histologyc | ||||||
| High grade | 214 (50.3) | 0.58 (0.40) | 0.02d | 114 (51.1) | 100 (49.3) | 0.71 |
| Medium grade | 67 (15.7) | 0.78 (0.70) | 32 (14.3) | 35 (17.2) | ||
| Low grade | 145 (34.0) | 0.62 (0.51) | 77 (34.5) | 68 (33.5) | ||
a
Comparison dichotomized at the median of B/C (0.48) among 426 study subjects.
b
Numbers do not add up to the column totals due to missing values.
c
High-grade glioma (glioblastoma), medium-grade glioma (anaplastic astrocytoma) and low-grade glioma (oligodendroglioma, not-otherwise-specified astrocytoma and mixed glioma).
d
Bold numbers indicate significant values at P <0.05.