Table 1.

miRNA knockout in mice

Gene	Expression	Phenotypes	Reference
miR-155	Thymus, spleen	Lung airway remodeling, defects in adaptive immunity	40
miR-155	Thymus, spleen	Impaired T-cell- and B-cell-dependent immunity	41
miR-17–92	Detectable in most adult tissues	100% postnatal death with cardiac and lung defects	47
miR-106a–363	Detectable in most adult tissues	No obvious phenotype	47
miR-106b–25	Detectable in most adult tissues	No obvious phenotype	47
miR-15a/16-1	Widely expressed	CLL-associated phenotypes at old age	67
miR-144/451	Erythroid lineage	Erythroid hyperplasia, splenomegaly, anemia	68
miR-451	Erythroid lineage	Similar to miR-144/451 mice	68
miR-150	Mature B and T cells	B1 cell expansion	71
miR-223	Myeloid cells	Expanded granulocyte lineage	73
miR-1-2	Heart, skeletal muscle	∼50% lethality with cardiac defects	43
miR-208a	Heart	Reduced cardiac hypertrophy in response to stress	42
miR-208a	Heart	Minor cardiac conduction defects	91
miR-208b	Heart, skeletal muscle	No obvious phenotype	56
miR-499	Heart, skeletal muscle	No obvious phenotype	56
miR-133a-1	Heart, skeletal muscle	No obvious phenotype	53
miR-133a-2	Heart, skeletal muscle	No obvious phenotype	53
miR-206	Skeletal muscle	No obvious phenotype	78
mRi-126	Endothelial cells	∼40% lethal with embryonic and perinatal hemorrhages	50
mRi-126	Endothelial cells	∼50% embryonic death with hemorrhages	49
miR-143/145	Developing heart, adult SMCs	Reduced media thickness in aorta	64
miR-143/145	Developing heart, adult SMCs	Synthetic smooth muscle cells, reduced media thickness	65
miR-143/145	Developing heart, adult SMCs	Thinner smooth muscle layers in vessels	66
miR-143	Developing heart, adult SMCs	No obvious phenotype	66
miR-145	Developing heart, adult SMCs	Similar to miR-143/145 mice	66
miR-375	Islet	Hyperglycemia	83
miR-140	Cartilage	Short stature and aged-related osteoarthritis	86
miR-182	Broad expression, high in eye	No obvious phenotype	89

SMC, smooth muscle cells; CLL, chronic lymphocytic leukemia.