Table 1.
Sequences and Phenotypes for CTD Mutants of Rpb1.
| CTD Mutant | Repeated Sequence | Cell Phenotype at around WT CTD Length |
| AL | ASPTSPS YSPTSPS | Lethal |
| AR | YSPTSPS YSPTAAA | Viable ++++ |
| YAA | YAATSPS YSPTSPS | Lethal |
| YATA | YAPTAPS YSPTSPS | Lethal |
| YAS | YASPTSPS YSPTSPS | Viable +++ |
| YAP | YAPTSPS YSPTSPS | Lethal |
| APS | YSPTAPS YSPTSPS | Viable ++++ |
| 252 | YSPTSPS YSPS | Viable +++++ |
| AA | AA YSPTSPS YSPTSPS | Viable ++++ |
| 5A | AAAAA YSPTSPS YSPTSPS | Slow growth + |
| 7A | AAAAAAA YSPTSPS YSPTSPS | Lethal |
| A7 | AAAAAAA YSPTSPS YSPTSPS YSPTSPS | Viable +++ |
| AP | AAPAAPA YSPTSPS YSPTSPS | Viable ++++ |
The “+” marks for each viable CTD mutant indicate the relative vigor of the yeast cells bearing the mutants, compared with WT cells (WT is labeled as five pluses).