Table 3.
Reported infections in selected JIIM phenotypes within 6 months of illness onset
| Age at diagnosis |
Race |
Myositis autoantibody |
|||||
|---|---|---|---|---|---|---|---|
| Infection characteristic | JIIM (n = 285), n (%) | ≤7.5 years (n = 150), n (%) | > 7.5 years (n = 135), n (%) | White (n = 199), n (%) | Other (n = 86), n (%) | Anti-p155 (n = 44), n (%) | Autoantibody negative (n = 52), n (%) |
| None | 175 (61) | 85 (57) | 90 (67) | 109 (55) | 66 (77) | 36 (82) | 28 (54) |
| No. of patients infected | 110 (39) | 65 (43) | 45 (33) | 90 (45)† | 20 (23)† | 8 (18)‡ | 24 (46)‡ |
| No. of infections | |||||||
| 1 | 75 (68) | 49 (75) | 26 (58) | 60 (67) | 15 (75) | 6 (75) | 17 (71) |
| 2 | 31 (28) | 13 (20)§ | 18 (40)§ | 27 (30) | 4 (20) | 2 (25) | 6 (25) |
| 3–5 | 4 (4) | 3 (5) | 1 (2) | 3 (3) | 1 (5) | 0 (0) | 1 (4) |
| Total no. of infections | 152 | 87 | 65 | 126 | 26 | 10 | 33 |
| Infection site¶ | |||||||
| Respiratory | 101 (66) | 54 (62) | 47 (72) | 84 (66) | 17 (65) | 5 (50) | 22 (67) |
| Mucocutaneous | 17 (11) | 10 (12) | 7 (11) | 14 (11) | 3 (12) | 2 (20) | 4 (12) |
| Gastrointestinal | 7 (5) | 7 (8) | 0 (0.0) | 7 (6) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Unclassified | 27 (18) | 16 (18) | 11 (17) | 21 (17) | 6 (23) | 3 (30) | 7 (21) |
| Most common infections¶ | |||||||
| Pharyngitis | 34 (22) | 13 (15)# | 21 (32)# | 32 (25) | 2 (8) | 2 (20) | 7 (21) |
| Flu or febrile illness | 19 (13) | 12 (14) | 7 (11) | 16 (13) | 3 (11) | 2 (20) | 6 (18) |
| Otitis media | 19 (13) | 15 (17) | 4 (6) | 16 (13) | 3 (11) | 1 (10) | 3 (9) |
| Upper respiratory infection | 16 (10) | 10 (11) | 6 (9) | 11 (9) | 5 (19) | 0 (0.0) | 3 (9) |
| Other | 64 (42) | 37 (43) | 27 (42) | 51 (40) | 13 (51) | 5 (50) | 14 (43) |
Conventions as per Table 2. Bold values represent P ≤ 0.05 after Holm’s adjustment for multiple comparisons (using family-wise error rates of 5%). †P = 0.0008; OR 2.7; 95% CI 1.5, 4.8. ‡P = 0.007; OR 3.9; 95% CI 1.5, 9.9. §P = 0.038; OR 2.7; 95% CI 1.1, 6.3. ¶Based on total number of infections, because some patients had >1 documented infection. P = 0.017; OR 2.7; 95% CI 1.2, 6.0.