Table 3.
Changes in serum urate levels (μmol/l) according to categories of weight change (kg)
| Weight change from baseline, kg | Number of visits, % | Unadjusted change (95% CI) | Multivariate changea (95% CI) | Multivariate changeb (95% CI) |
|---|---|---|---|---|
| Loss ≥10 | 2837 (3.60) | −34 (−37, −31) | −37 (−40, −35) | −37 (−40, −35) |
| Loss 5–9.9 | 8511 (10.79) | −13 (−14, −11) | −18 (−20, −17) | −19 (−20, −17) |
| Loss 1–4.9 | 19 055 (24.16) | −3 (−4, −2) | −7 (−8, −6) | −7 (−9, −6) |
| No change (−0.9 to 0.9) | 25 475 (32.30) | 0 (Referent) | 0 (Referent) | 0 (Referent) |
| Gain 1–4.9 | 15 951 (20.22) | 9 (7, 10) | 6 (5, 7) | 5 (4, 7) |
| Gain 5–9.9 | 5502 (6.98) | 23 (21, 25) | 18 (16, 20) | 17 (16, 19) |
| Gain ≥10 | 1550 (1.96) | 34 (31, 38) | 26 (23, 30) | 26 (23, 29) |
| P-value for trend | <0.001 | <0.001 | <0.001 |
aLinear mixed model adjusted for baseline covariates (race, education level and weight categories), and time-varying covariates (i.e. age, congestive heart failure, hypertension, diuretic use and serum creatinine levels). bLinear mixed model further adjusted for time-varying alcohol intake and dietary factors (i.e. intakes of fructose, caffeine, total protein, polyunsaturated fat, monounsaturated fat, saturated fat and fibre).