Table 1. Global transmission disequilibrium tests (HAP-TDT) of all three best two-marker haplotype combinations (according to p-values) in the genomic region covering the melanocortin 4 receptor gene (MC4R) in 424 obesity trios of the detection sample, the confirmation sample of 363 obesity trios and in the joint sample of 787 obesity trios.

	1st SNP of two-marker haplotype	chrom.18 physical position in base pairsa	2nd SNP of two-marker haplotype	chrom.18 physical position in base pairsa	detection sample (424 obesity trios) p-valueb	confirmation sample (363 obesity trios) p-valueb	joint sample (787 obesity trios) p-valueb	joint sample (787 obesity trios) hRRc for obesity risk haplotype [95% CI]
Haplo 1	rs17700028	55,926,664	rs12970134	56,035,730	5.2×10−4	0.039	5.7×10−4	3.24 [0.36–29.12]
Haplo 2	rs12970134	56,035,730	rs1943226	56,186,184	5.2×10−4	0.093	6.0×10−5	1.48 [1.23–1.78]
Haplo 3	rs12970134	56,035,730	rs1943229	56,237,438	0.001	0.074	1.7×10−4	1.61 [1.30–2.00]

^abase pair position on chromosome 18 according to http://www.ncbi.nlm.nih.gov (hg18);

^bpermutation-based p-value based on 10⁶ simulations;

^chaplotypic relative risk (hRR) relative to the most frequent haplotype for the haplotype comprising the two obesity risk alleles of the 1^st and 2^nd SNP with 95% confidence intervals (95% CI).