Figure 5.

Mouse arterial thrombosis models. (A) C57Bl/6 mice of the genotypes indicated at the right of the panel were tested in a carotid artery thrombosis model at FeCl₃ concentrations from 2.5% to 15% (10 animals per concentration), as described in “Methods.” Bar heights indicate percent of mice in each group with patent arteries 30 minutes after applying FeCl₃. (B) Time to carotid arterial occlusion in wild-type (n = 16), fXI-deficient (n = 12), or fXII-deficient (n = 15) mice in a Rose Bengal-laser injury model, as described in “Methods.” Error bars indicate 1 standard deviation. Time to occlusion is significantly longer for fXI^−/− than wild-type mice (*P = .0012), for fXII^−/− than wild-type mice (**P = .0001) and for fXII^−/− than fXI^−/− mice (**P = .0031). (C) Results from the FeCl₃ carotid artery thrombosis model (panel A), comparing the effect of treatment with an intravenous infusion of 14E11 (1.0 mg/kg) into wild-type mice () to results for 7.5% and 10% FeCl₃ from panel A.