Table 1. Expression of a selected panel of genes associated with osteolytic bone disease as a function of substrate rigidity.

	MDA-MB-231		RWGT2		MCF-7
Gene	3.3 MPa	1700 MPa	3.3 MPa	1700 MPa	3.3 MPa	1700 MPa
IL-11	1.5	1.4	1.1	1.1	1.1	−1.1
OPN	−18	−18	−5.0	−2.3	1.4	−1.1
MMP-9	−32	−11	−1.3	−1.4	3.7	1.3
CXCR4	−2.0	1.1	1.4	1.7	2.4	1.3
CTGF	1.8	2.0	1.1	1.0	2.4	1.3

Values are listed as fold increase in gene expression compared to that measured for the PAA hydrogel.