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. Author manuscript; available in PMC: 2011 Oct 25.
Published in final edited form as: J Chem Inf Model. 2010 Oct 25;50(10):1759–1771. doi: 10.1021/ci100200u

Figure 4.

Figure 4

Sequence alignment example. Comparison of PDB-ID 1T7J and the HXB2 protein sequence. Amino acid differences are identified (underlined) which is then compared against the list of crystallized mutations. Any mutations found in the list of artificial mutations required for viable crystal structures (Q7K) are then removed to obtain the final list of mutations for 1T7J.