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. Author manuscript; available in PMC: 2011 Nov 26.
Published in final edited form as: J Mol Biol. 2010 Sep 25;404(2):274–290. doi: 10.1016/j.jmb.2010.09.044

Figure 9.

Figure 9

The line fishing model for assembling the endocytic apparatus. After docking to the plasma membrane via interactions between the N-terminal ANTH domain of AP180 (yellow) and membrane bound PIP2, the long and flexible C-terminal domain of AP180 (red) can bind and recruit clathrin (black) from a large volume of cytosol to initiate the formation of a clathrin coated pit. The large number of clathrin binding sites (green) recruit multiple clathrin heavy chains together to form the vertexes of the clathrin lattice (adapted from31 with permission from the Journal of Biological Chemistry).