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pH dependence of (a) fluorine NMR (5°C, ≠ impurity) and (b) CD spectra (20°C)[pH 7.0 (red); pH 7.0→9.0 (blue); pH 7.0→9.0 →7.0 (green)] of the FAAF-modified duplex II. c) a Hoogsteen-type syn-dG[FAAF]:anti-dC alignment.