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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Glia. 2010 Sep 27;59(1):1–13. doi: 10.1002/glia.21071

Figure 8. BzATP abrogates LPS-induced HT22 hippocampal neuron death via P2X7 receptors.

Figure 8

Parental N9 and shP2X7/N9 cells were treated overnight with vehicle (250 mM Hepes) or LPS (1 μg/mL) in the presence and absence of BzATP (150 μM). Microglial conditioned medium was applied to HT22 neurons for 18-22 hours after which time neuron survival was assessed by the MTS mitochondrial function assay. The data are graphed as % of neurons surviving relative to control treatment and represent the means of 3-6 independent experiments ± SEM. ** p<0.01 vs. control; ***p<0.001 vs. control; §§ p<0.01 vs. LPS.