Fig. 4.
Effect of hydrogen peroxide and delphinidin on the level of p27kip1 in wild type hepa1c1c7 (A) and HIF-1β-deficient BPRc1 (B) cells. Mouse hepatoma hepa1c1c7 (HIF-1β-positive) and its mutant BPRc1 (HIF-1β-negative) were treated with various doses of delphinidin in the presence of 100 µM H2O2, followed by the determination of p27kip1 level. Data are representative of three independent experiments as mean ± SD. Values on bars not sharing a common superscript significantly differ from each other (P < 0.05).