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. Author manuscript; available in PMC: 2010 Nov 16.
Published in final edited form as: Cancer Res. 2009 Apr 14;69(9):3856–3865. doi: 10.1158/0008-5472.CAN-08-2940

Figure 4.

Figure 4

3TSR regulates expression of the proapoptotic death receptors DR4 and DR5. A, 3TSR treatment of HDMEC for 1 to 12 h significantly increased expression of DR4 and DR5 at the transcriptional level. B and C, 3TSR treatment of HDMEC for 1 to 12 h increased both DR4 and DR5 protein expression, whereas 3TSR treatment of HDMEC for 8 h increased both DR4 and DR5 expression in a concentration-dependent manner. D, pretreatment of HDMEC cells with DR4- and/or DR5-blocking antibody for 30 min inhibited 3TSR-mediated apoptosis.