Table I. Outcome after renal transplantation to presensitized recipients at the time of the second renal homotransplantation, in relation to the preformed antibody titers (expressed as reciprocal of dilution).
Experiment No. | Lymphocytotoxins | Hemagglutinins | Leukoagglutinins | Thromboagglutinins* | Rejection time |
---|---|---|---|---|---|
Control animals | |||||
2 | 128 | 4 | 32 | 8 | 14 min. |
7 | 256 | 2 | 0 | 4 | 20 min. |
8 | 0 | 0 | 0 | 2 | 35 min. |
Citrate-treated animals | |||||
3 | 256 | 8 | 4 | 8 | 7 hr. |
6 | 2 | 32 | 8 | 32 | 24† hr. |
9 | 64 | 0 | 4 | 2 | 6.5 hr. |
10 | 64 | 32 | 0 | 2 | 48† hr. |
Thromboagglutinins were present even before sensitization in four of these seven dogs. In contrast, the lymphocytotoxins, hemagglutinins, and leukoagglutinins developed in response to the sensitization.
Rejection had not occurred when the homograft was removed.