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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Gut. 2010 Jul;59(7):888–895. doi: 10.1136/gut.2009.204990

Figure 2.

Figure 2

Intestinal Gata4 deletion results in an induction of taurocholate (TC) uptake in proximal small intestine, and a depletion of luminal bile acids in distal small intestine. Ex vivo measurements of TC transport in everted gut sacs show (a) a significant increase in mucosal-to-serosal transport of radioactively labelled TC in proximal intestine of G4ap mice as compared with Wt-controls, and (b) a corresponding increase in tissue-associated TC. *p<0.05, **p<0.01, ***p<0.001, as compared with Wt-controls, n=5 in each group. In vivo segmental analysis reveals that the amount of bile acid in luminal contents (c) and tissue (d) is reduced in distal small intestine of G4ap mice as compared with Wt-controls. *p<0.05, **p<0.01, as compared with Wt-controls, n=6 for G4ap mice, n=5 for Wt-control mice.