Intestinal Gata4 recombination prevents a loss of bile acids in the body pool after ICR. Bile acid (BA) pool size, as determined by the total bile acid content in liver, gall bladder and small intestine, is lower in Wt-control mice that underwent ileocaecal resection (ICR) as compared with sham-operated mice. Bile acid pool size in G4Δex2 and G4ap mice that underwent ICR remains similar to that of their sham-operated counterparts. *p<0.05, as compared with sham-operated mice, n=3–7 in each group.