Table 5.

Nature of K-ras Exon1 mutations in colorectal cancer patients from Kashmir valley

Patient ID	Age/Sexa	Rural/Urbanb	Duke's stagec	Smoking statusd	Node statuse	Sitef	Typeg	Natureh	Codon number	Base changei	Aminoacid change
1X	55/M	R	A	NSk	N	C	AC	HNPCC	12	GGT > GAT	Gly > Asp
4X	47/F	R	D	Sk	P	R	MAC	S	12, 13	GGT > GAT,	Gly > Asp
										GGC > GAC
8X	51/M	U	B	NSk	N	C	AC	S	13	GGC > GAC	Gly > Asp
17X	67/F	R	D	Sk	P	R	MAC	S	12	GGT > GAT	Gly > Asp
23X	71/M	R	C	Sk	P	R	MAC	S	12	GGT > GAT	Gly > Asp
25X	50/F	U	B	Sk	N	C	AC	S	13	GGC > GAC	Gly > Asp
30X	44/F	R	D	Sk	P	C	MAC	S	12	GGT > GAT	Gly > Asp
38X	45/M	U	D	NSk	P	C	MAC	S	12	GGT > GAT	Gly > Asp
40X	50/M	R	D	NSk	P	R	MAC	S	12	GGT > GAT	Gly > Asp
44X	61/M	R	B	Sk	N	C	AC	S	13	GGC > CGC	Gly > Arg
47X	60/F	R	B	Sk	N	C	AC	s	13	GGC > TGC	Gly > Cys
51X	58/M	R	C	Sk	P	C	MAC	s	12	GGT > AGT	Gly > Ser

^aAge/Sex: M = Male, F = Female;

^bRural/Urban: R = Rural, U = Urban;

^cDuke's stage: A -Tumor confined to the intestinal wall; B - Tumor invading through the intestinal wall; C - With lymph node(s) involvement; D - With distant metastasis;

^dSmoking Status: Sk: Smokers; NSk: Nonsmokers;

^eNode Status: N = Negative, P= Positive;

^fSite of tumor: C = Colon, R = Rectum;

^gTumorType: AC = NonmucinousAdenocarcinoma, MAC = MucinousAdenocarcinoma;

^hNature of tumor: S: Sporadic; HNPCC: Hereditary Nonpolyposis Colorectal Cancer;

ⁱBase change: Mutated or inserted nucleotide underlined