Table 1.
Association between autoimmune diseases, neoplasms and pathogens as found by NCBI MeSH.
| pathogen | autoimmune disease | # co-occurrence | pathogen | neoplasm | # co-occurrence |
|---|---|---|---|---|---|
| Measles virus | Multiple Sclerosis | 384 | Papillomaviridae | Uterine Cervical Neoplasms | 5854 |
| Herpesvirus 4, Human | Arthritis, Rheumatoid | 279 | Helicobacter pylori | Stomach Neoplasms | 3231 |
| Campylobacter jejuni | Guillain-Barre Syndrome | 167 | Papillomaviridae | Carcinoma, Squamous Cell | 2252 |
| Enterovirus B, Human | Diabetes Mellitus, Type 1 | 164 | Papillomaviridae | Cervical Intraepithelial Neoplasia | 1922 |
| Campylobacter jejuni | Polyradiculoneuropathy | 150 | Herpesvirus 4, Human | Cell Transformation, Viral | 1899 |
| Herpesvirus 4, Human | Multiple Sclerosis | 136 | Herpesvirus 4, Human | Burkitt Lymphoma | 1853 |
| Herpesvirus 4, Human | Lupus Erythematosus, Systemic | 126 | Hepatitis B virus | Liver Neoplasms | 1673 |
| Helicobacter pylori | Purpura, Thrombocytopenic, Idiopathic | 124 | Hepatitis B virus | Carcinoma, Hepatocellular | 1615 |
| Theilovirus | Multiple Sclerosis | 118 | Herpesvirus 4, Human | Nasopharyngeal Neoplasms | 1518 |
| Herpesvirus 6, Human | Multiple Sclerosis | 113 | Herpesvirus 8, Human | Sarcoma, Kaposi | 1391 |
| Mycobacterium tuberculosis | Arthritis, Rheumatoid | 110 | Hepacivirus | Carcinoma, Hepatocellular | 1005 |
| Escherichia coli | Arthritis, Rheumatoid | 101 | Hepacivirus | Liver Neoplasms | 996 |
| Chlamydophila pneumoniae | Multiple Sclerosis | 74 | Herpesvirus 4, Human | Hodgkin Disease | 975 |
| Streptococcus pyogenes | Arthritis, Rheumatoid | 61 | Simian virus 40 | Cell Transformation, Viral | 860 |
| Human T-lymphotropic virus 1 | Multiple Sclerosis | 61 | Herpesvirus 4, Human | Lymphoma | 753 |
| Lymphocytic choriomeningitis virus | Diabetes Mellitus, Type 1 | 61 | Oncogenic Viruses | Neoplasms | 720 |
| Rubella virus | Multiple Sclerosis | 61 | Helicobacter pylori | Lymphoma, B-Cell, Marginal Zone | 704 |
Table 1 lists the most frequent co-occurrences found between disease (autoimmune disorders and malignancies) and pathogen terms according to MeSH term mining of scientific literature given in Medline. HHV4 (EBV) entries are given in bold.