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. 2010 Nov 15;21(22):3952–3962. doi: 10.1091/mbc.E10-04-0293

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© 2010 by The American Society for Cell Biology

This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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Figure 6. — Increased p21 expression in B⁻C⁻/B⁻C⁻ cardiac myocytes. (A) Immunoblot analysis of p21 expression from 5 and 2 μg of E13.5 mouse heart extracts shows increased expression of p21 in B⁻C⁻/B⁻C⁻ hearts compared with B⁺C⁺/B⁺C⁺ hearts. Actin expression is used as a loading control. (B) Immunofluorescence confocal images of E13.5 heart sections from B⁺C⁺/B⁺C⁺ (a and b) and B⁻C⁻/B⁻C⁻ (c and d) mice stained for p21 (green). DAPI stains the nuclei (blue). B⁻C⁻/B⁻C⁻ cardiac myocytes (large nuclei) but not the nonmyocytes show increased p21 expression (c, green) compared with B⁺C⁺/B⁺C⁺ cardiac myocytes (a, green). Note the multilobed nuclei of B⁻C⁻/B⁻C⁻ cardiac myocytes (d, arrows).