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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Expert Opin Ther Targets. 2010 Dec;14(12):1323–1332. doi: 10.1517/14728222.2010.528395

Figure 4.

Figure 4

MKP-1 regulates MAPK-dependent signaling in metabolism. (A) The transcriptional co-activator, PGC-1α, is phosphorylated by p38 MAPK which promotes its stability and subsequent activity. MKP-1 dephosphorylates p38 MAPK resulting in reduced PGC-1α phosphorylation and function. (B) In obesity, MKP-1 is overexpressed in skeletal muscle resulting in reduced PGC-1α phosphorylation and activity. The loss of PGC-1α̣ activity impairs the capacity to maintain oxidative myofibers resulting in an increased susceptiblity of high energy consuming oxidative myofibers to switch to less energy consuming glycolytic myofibers.