Table 2.
Results of BLM and NetLapRLS based on cross validation experiments 5 times
| Data | Methods | AUC | AUPR | Sensitivity(%) | Specificity(%) | PPV(%) |
|---|---|---|---|---|---|---|
| * Enzyme | BLM | 96.8(0.1) | 85.2(0.2) | 83.2(0.2) | 99.82(0.002) | 82.3(0.2) |
| NetLapRLS | 95.6(0.3) | 82.6(0.6) | 81.0(0.5) | 99.80(0.005) | 80.2(0.5) | |
| * Ion channel | BLM | 97.2(0.1) | 83.2(0.4) | 28.0(0.03) | 99.96(0.001) | 96.4(0.1) |
| NetLapRLS | 94.7(0.3) | 82.5(0.5) | 28.4(0.14) | 99.98(0.005) | 98.1(0.5) | |
| * GPCR | BLM | 94.4(0.3) | 65.0(1.6) | 28.0(0.8) | 99.83(0.02) | 83.9(2.4) |
| NetLapRLS | 93.1(0.3) | 66.0(1.5) | 29.2(0.8) | 99.87(0.03) | 87.5(2.4) | |
| Nuclear Receptor | BLM | 84.1(0.9) | 58.4(2.2) | 14.0(0.6) | 99.89(0.04) | 90.0(3.9) |
| NetLapRLS | 85.6(1.8) | 51.6(2.3) | 15.1(1.0) | 99.97(0.07) | 97.1(6.1) |
The AUC and AUPR scores are normalized to 100. The cutoff for sensitivity, specificity and PPV is set to choose the top one percentile in the predictoin score as positive.