Table 3.
The Effect of PLA2 BanI Genotypes on the HDRS Symptom Clusters in Groups of Patients with IFN-α–Induced Depression and Patients with Major Depressive Disorder
| IFN-α–Induced Depression |
Major Depressive Disorder |
|||||
|---|---|---|---|---|---|---|
| HDRS Clusters Scoresa | GG | AG/AA | p | GG | AG/AA | p |
| Core | 11.1 ± 1.3 | 10.7 ± 2.2 | .6 | 15.6 ± 2.8 | 15.1 ± 2.3 | .5 |
| Sleep | 4.0 ± 1.3 | 3.7 ± 1.9 | .7 | 3.4 ± 2.4 | 3.5 ± 1.6 | .8 |
| Activity | 3.1 ± 1.5 | 2.9 ± .7 | .7 | 3.9 ± 1.6 | 3.8 ± 1.4 | .8 |
| Psychic Anxiety | 2.0 ± 1.3 | 2.0 ± 1.0 | .8 | 4.1 ± 1.6 | 4.5 ± 1.6 | .5 |
| Somatic Anxiety | 5.9 ± 1.1 | 4.2 ± 1.2 | .002b | 5.8 ± .7 | 4.5 ± 1.7 | .01 |
| Delusion | 2.1 ± .9 | 2.0 ± 1.2 | .8 | 4.8 ± 2.3 | 3.8 ± 1.8 | .2 |
| Total HDRS | 24.0 ± 5.0 | 21.3 ± 4.1 | .1 | 29.3 ± 7.1 | 27.3 ± 5.4 | .3 |
PLA2, phospholipase A2; HDRS, Hamilton Depression Rating Scale; INF, interferon.
a
The HDRS items were divided into the six clusters: Core (items 1, 2, 7, 8, 10, 13), Sleep (items 4, 5, 6), Activity (items 7, 8), Anxiety (items 9, 10, 11, 12, 13), Psychic Anxiety (items 9, 10), Somatic Anxiety (items 11, 12, 13), and Delusion (items 2, 15, 20) (40,62).