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Docking PTB onto the PV IRES. Strong and medium cleavages caused by the designated Fe(II)-PTB derivatives are shown as in Figure 3C. The deduced orientation of PTB binding is also shown in the same colour code: transparent green denotes RBD1, RBD2 is pink and the RBD3+4 di-domain is transparent blue. The proposed position of the central domain of eIF4G (de Breyne et al, 2009) is shown by the dashed oval line.
