| CMMCs evoked by local reflexes |
|
|
|
|
| Mucosal brush strokes, area under the curve mN-s |
343.85 ± 35.61 |
65.85 ± 20.26 |
4 |
<.01 |
| Circumferential stretch, area under the curve mN-s |
374.85 ± 46.2 |
343.72 ± 20.26 |
4 |
>.05 |
|
|
Alosetron, 5 μmol/L
|
|
|
| Mucosal brush strokes, area under the curve mN-s |
288.7 ± 33.6 |
45.7 ± 20.3 |
4 |
<.01 |
| Circumferential stretch, area under the curve mN-s |
333.4 ± 46.2 |
326.7 ± 33.6 |
4 |
>.05 |
|
|
Ondansetron, 1–3 μmol/L
|
|
|
| CMMCs evoked by a fixed pellet |
|
|
|
|
| Resting membrane potential, mV |
62.47 ± 2.61 |
60.98 ± 3.63 |
5 |
>.05 |
| Interval between CMMCs, s |
225.22 ± 39.54 |
Blocked |
4 |
<.01 |
| Duration of CMMCs, s |
50.39 ± 2.46 |
Blocked |
4 |
<.01 |
| Amplitude of hyperpolarization, mV |
12.18 ± 0.50 |
Blocked |
4 |
<.01 |
| Amplitude of depolarization, mV |
15.35 ± 1.41 |
Blocked |
4 |
<.01 |
| Number of action potentials on depolarization |
2.60 ± 0.27 |
Blocked |
4 |
<.01 |
|
|
Ondansetron, 1–3 μmol/L
|
|
|
| Spontaneous junction potentials |
|
|
|
|
| Interval between IJPs, s |
2.10 ± 0.15 |
12.05 ± 0.65 |
5 |
<.05 |
| Amplitude of IJPs, mV |
10.05 ± 0.57 |
4.79 ± 0.57 |
5 |
<.05 |
| Duration of IJPs, mV |
0.65 ± 0.03 |
0.58 ± 0.05 |
5 |
<.05 |
| Duration of EJPs, s |
0.60 ± 0.05 |
1.23 ± 0.11 |
5 |
<.05 |
| Amplitude of EJPs, mV |
8.49 ± 0.59 |
9.34 ± 0.25 |
5 |
>.05 |
|
Atropine, 1 μmol/L
|
Ondansetron, 1 μmol/L
|
|
|
| CMMCs evoked by TNS (no mucosa) |
|
|
|
|
| Amplitude of depolarization, mV |
16.42 ± 1.55 |
17.19 ± 1.55 |
5 |
>.01 |
| Duration of depolarization, s |
44.81 ± 5.66 |
49.7 ± 4.34 |
5 |
>.01 |
| Amplitude of hyperpolarization, mV |
13.44 ± 2.05 |
3.74 ± 0.36 |
5 |
<.01 |
| Duration of hyperpolarization, s |
44.81 ± 5.66 |
21.85 ± 2.48 |
5 |
<.01 |
