Table 4.
Multivariate Cox Regression Analyses for Nodal Micrometastasis and for Nodal Macrometastases
| Variable | df | Nodal Micrometastases (n = 1,872) |
Nodal Macrometastases (n = 441) |
||||
|---|---|---|---|---|---|---|---|
| χ2 | P | Hazard Ratio | χ2 | P | Hazard Ratio | ||
| No. of positive nodes | 2 | 50.5 | < .001 | 14.7 | < .001 | ||
| 1* | — | — | — | 1.00 | — | — | 1.00 |
| 2-3 | 1 | 3.5 | .0617 | 1.22 | 3.2 | .0741 | 1.34 |
| ≥ 4 | 1 | 50.4 | < .001 | 2.94 | 14.6 | < .001 | 1.95 |
| Thickness, mm | 3 | 43.5 | < .001 | 6.1 | .1057 | ||
| ≤ 2.00* | — | — | — | 1.00 | — | — | 1.00 |
| 2.01-4.00 | 1 | 7.8 | .0052 | 1.44 | 5.1 | .0244 | 0.62 |
| 4.01-6.00 | 12.0 | .0005 | 1.72 | 1.1 | .2995 | 0.79 | |
| > 6.00 | 1 | 41.6 | < .001 | 3.07 | 0.3 | .5555 | 0.88 |
| Ulceration | 1 | 25.0 | < .001 | 8.2 | .0043 | 1.54 | |
| Absent* | — | — | — | 1.00 | — | — | 1.00 |
| Present | 1 | 25.0 | < .001 | 1.67 | 8.2 | .0043 | 1.54 |
| Clark level | 1 | 0.1 | .7463 | 3.5 | .0629 | ||
| II/III* | — | — | — | 1.00 | — | — | 1.00 |
| IV/V | 1 | 0.1 | .7463 | 0.96 | 3.5 | .0629 | 1.50 |
| Age, years | 2 | 28.1 | < .001 | 22.5 | < .001 | ||
| < 50* | — | — | — | 1.00 | — | — | 1.00 |
| 50-69 | 1 | 11.0 | < .001 | 1.42 | 1.1 | .3024 | 0.85 |
| ≥ 70 | 1 | 26.3 | < .001 | 2.02 | 14.6 | .0001 | 2.05 |
| Site | 1 | 9.0 | .0027 | 4.4 | .0368 | ||
| Extremity* | — | — | — | 1.00 | — | — | 1.00 |
| Axial | 1 | 9.0 | .0027 | 1.35 | 4.4 | .0368 | 1.34 |
| Sex | 1 | 4.7 | .0305 | 0.2 | .6619 | ||
| Male* | — | — | — | 1.00 | — | — | 1.00 |
| Female | 1 | 4.7 | .0305 | 0.80 | 0.2 | .6619 | 1.07 |
NOTE. No. of patients = 2,313 and includes all Stage III patients with data available on the listed seven variables.
*
Reference for hazard ratio calculation.