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. 2010 Nov 16;4(11):e886. doi: 10.1371/journal.pntd.0000886

Figure 4. NO production by macrophages stimulated with IFN-γ + Leishmania is inhibited by LXR ligands.

Figure 4

BMDM were preincubated overnight with LXR (GW  =  GW3965) and RXR (LG  =  LG268) ligands, with or without IFN-γ, prior to a 1 hour in vitro infection with stationary-phase L. chagasi/infantum. Amount of NO secreted in 24 hours by wild-type BMDM stimulated with IFN-γ + Leishmania in the absence of ligand was normalized to 100%. L-NNMA is a NOS inhibitor. Error bars represent standard deviations of triplicate NO measurements. Results are representative of at least 3 independent experiments; ** denotes p<0.005.