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. Author manuscript; available in PMC: 2011 Nov 23.
Published in final edited form as: Biochemistry. 2010 Oct 29;49(46):9972–9984. doi: 10.1021/bi1014858

Figure 1. The V617F mutation induces a possible π stacking interaction between F594, F595 and F617 in Jak2.

Figure 1

(A, B) Cartoon representations of the Jak2-WT and Jak2-V617F JH2 domain homology models, respectively, generated using SWISS MODEL and visualized with Chimera. (C, D) The distances between F594 (white), F595 (yellow) and 617 (magenta) were lesser in Jak2-V617F when compared to Jak2-WT. All the distances were calculated using the Structural Analysis tools in Chimera.