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Multiple sequence alignment of the human Jak2 primary amino acid sequence with different species (A) and with other human JAK family members (B). Sequence conservation at F594 and F595 are highlighted in blue and that at position V617 is shown in orange. The non-conserved amino acid at 595 is highlighted in pink and that at 617 is shown in green. The reference sequence positions are indicated for human Jak2 protein.
