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Plasma cytokine levels following multiple dose (four weekly doses) i.v. administration of various pSi S1MP nanovectors. The animals were sacrificed on the 5th week from the first injection. The treatments included saline, silicic acid equivalent to the 108 of the S1MP particles injected, negatively (oxidized) and positively (APTES) charged particles at the dose of 108 particles per mouse (n=4–6).
