Table 1.
Biochemical analysis of plasma samples following single-dose i.v. administration of various S1MP pSi nanovectors. The treatment included saline, silicic acid equivalent to the 5× 108 of the pSi particles injected, negatively (oxidized) and positively (APTES) charged particles at three doses (107, 108 and 5×108 particles per mouse). The results are presented as mean ± S.D
| Treatments | LDH(IU/L) | Arginase(U/L) | Urea(mg/dL) | Creatinine (mg/dL) |
|---|---|---|---|---|
| Saline | 127.0± 10.4 (n=2) | 10.7±2.9 (n=3) | 55.3±13.8 (n=4) | 0.43±0.04 (n=4) |
| Silicic acid | 82.9±7.2 (n=4) | 11.6±3.9 (n=4) | 38.1±3.1 (n=5) | 0.43±0.01 (n=4) |
| APTES 107 | 99.7± 17.4 (n=5) | 11.1±3.4 (n=3) | 41.3±4.8 (n=6) | 0.49±0.03 (n=5) |
| APTES 108 | 115.4± 29.1 (n=5) | 11.9±1.8 (n=6) | 47.9±9.2 (n=6) | 0.46±0.08 (n=6) |
| APTES 5×108 | 186.8±22.0 (n=3) | 9.4±3.0 (n=5) | 52.1±13.4 (n=6) | 0.43±0.03 (n=5) |
| Oxidized 107 | 167.2±26.9 (n=5) | 10.4±3.2 (n=4) | 58.4±8.6 (n=6) | 0.48±0.17 (n=4) |
| Oxidized 108 | 145.2±23.6 (n=4) | 12.8±4.4 (n=5) | 60.7±6.6 (n=6) | 0.61±0.09 (n=3) |
| Oxidized 5×108 | 175.7±32.8 (n=4) | 15.9±2.7 (n=6) | 49.3±5.5 (n=6) | 0.5±0.08 (n=6) |