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. Author manuscript; available in PMC: 2011 Nov 23.
Published in final edited form as: Biochemistry. 2010 Oct 29;49(46):9964–9971. doi: 10.1021/bi1012996

Figure 4.

Figure 4

Superposition of p53 TAD and NCBD structures. (a) The backbone of the p53 TAD in the complex with NCBD is shown as a green tube. The p53 TAD structures in the complex with other proteins are aligned on the backbone heavy atoms of Pα1 and Pα2 of p53 TAD in the complex with NCBD. The AD1 region of the p53 TAD in the complex with MDM2 is shown in magenta. The AD2 region of the p53 TAD in the complexes with RPA and TFIIH is shown in red and blue, respectively. (b) Superposition of the structures adopted by the NCBD in complexes with the p53 TAD (blue), ACTR (orange), and SRC1 (cyan). The NCBD backbone is shown as a ribbon, and the structures are superimposed on the backbone heavy atoms of residues in the Cα1 and Cα2 helices of the NCBD.