Table 2.

Thermodynamic parameters obtained from isothermal titration calorimetry experiments for complexes of p53 TADs and NCBD

Complex	ΔH (kcal/mole)	−TΔS (kcal/mole)	Kd (μM)
p53 (13–61)/NCBD	−4.42 ± 0.15	−3.37 ± 0.19	3.1 ± 0.2
p53 (13–61,D49A)/NCBD	−2.09 ± 0.45	−5.37 ± 0.41	5.1 ± 0.3
p53 (25–61)/NCBD	−4.12 ± 0.46	−3.32 ± 0.59	5.4 ± 1.8
p53 (38–61)/NCBD	−4.60 ± 0.12	−2.26 ± 0.10	13.5 ± 0.54