Table 1.
Human neoplasms where miR-15/107 gene members are down-regulated and granulin expression is up-regulated.
Studies in multiple subtypes of human neoplasms have observed miR-15/107 gene member down-regulation and granulin up-regulation. Both miR-15/107 genes and GRN have been found to be dysregulated in other tumor types, but here are shown the tumor types where both were independently verified. The miR-15/107 gene group comprises miR-15a, miR-15b, miR-16, miR-103, miR-107, miR-195, miR-424, miR-497, miR-503, and miR-646. The methods used for the various studies are indicated in parentheses. ″Other″ methods to detect downregulated miRNAs include Northern blots, specialized high-throughput methods, and in situ hybridization.
| Carcinomas | miR-15/107 group member downregulated ? (METHODS) | miRNA downregulated in this cancer: | Granulin upregulated ? (METHODS) | REFS |
|---|---|---|---|---|
| Bladder carcinoma | YES (A) | miR-195 | YES (G) | 1 |
| Endometrial carcinoma | YES (C) | miR-424 | YES (G) | 2 |
| Gastric carcinoma | YES (A,D) | miR-195 | YES (F) | 3 |
| Head and neck carcinoma | YES (A,B) | miR-16, -195 | YES (G) | 4 |
| Hepatocellular carcinoma | YES (B, D) | miR-15b, -16 | YES (G) | 5 |
| Breast carcinoma | YES (B) | miR-16, -497 | YES (G) | 6 |
| Non-small cell lung carcinoma | YES (B) | Multiple | YES (F) | 7 |
| Ovarian carcinoma | YES (B) | miR-195 | YES (G) | 8 |
| Prostatic carcinoma | YES (A) | miR-15,-16,-107 | YES (G) | 9 |
| Hematological malignancies | ||||
| Chronic lymphocytic leukemia | YES (C,D) | miR-15a, 16 | YES (E) | 10 |
| Multiple myeloma | YES (A) | miR-15a | YES (G) | 11 |