Elevated cytokine expression in the adult hippocampus at ~5 months after WBI (Sham, n = 10; Sham-Run, n = 10; IRR, n = 10; IRR-Run, n = 9). All data are expressed as pg of cytokine protein per μl of total protein, and represent group means. Error bars indicate SEM. A, hippocampal TNF-α expression at ~5 mo after sham- or WBI. * significantly different from Sham and Sham-Run groups at p < 0.001. B, hippocampal INF-γ expression at ~5 mo after sham- or WBI. IFN-γ protein levels in Sham and Sham-Run mice were < 1 pg/μl. * significantly different from Sham and Sham-Run groups at p < 0.001. C, hippocampal IL-6 expression at ~5 mo after sham- or WBI. * significantly different from Sham and Sham-Run groups at p < 0.001.