A, High-resolution 500 MHz 1H-NMR spectra of liver extracts from ATM+/+/ApoE−/− and ATM+/−/ApoE−/− mice. Top,
β-Hydroxybutyrate, lactate, and alanine peaks are labeled. Bottom, Multiple peaks show the glucose region in NMR spectra. B,
β-Hydroxybutyrate concentrations in liver, pancreas, and plasma of ATM+/−/ApoE−/− mice. Data are shown as relative changes in ATM+/+/ApoE−/− compared with ATM+/+/ApoE−/− mice (means±SEM). *P<0.05, **P<0.01. C, Major lipid changes in the liver and pancreas. Data are shown as relative changes in ATM+/+/ApoE−/− compared with ATM+/+/ApoE−/− mice (means±SEM). *P<0.05, **P<0.01, ***P<0.001. Black bars indicate ATM+/+/ApoE−/−; unfilled bars, ATM+/−/ApoE−/−.