Table.

Atherosclerosis Is Increased in ATM^+/−/ApoE^−/− Mice

			Bone Marrow Transplant
	ATM+/+ (n=13)	ATM+/− (n=15)	ATM+/+ → ATM+/+ (n=7)	ATM+/+ → ATM+/− (n=8)
Aortic Plaque area (mm2)	4.76±1.07	8.26±2.32*	2.78±0.73	2.03±0.91
Aortic Root per Plaque area (μm2)	63.93±12.9	103.14±17.4*	81.94±22.5	114.17±22.4
SMA positive area (%)	5.68±1.72	4.23±0.83	13.92±6.94	11.9±2.92
MAC positive area (%)	39.81±3.53	32.42±4.63	46.47±10.14	58.66±6.99
Necrotic core area (%)	34.35±4.15	34.30±5.74	71.91±5.57	66.31±3.39
Ki67 positive cells (%)	0.68±0.10	0.29±0.1	0.89±0.20	2.15±0.55*
Cleaved caspase 3–positive cells (%)	0.55±0.07	0.22±0.07*	0.82±0.15	0.28±0.17*

Left columns: atherosclerotic plaque areas, % SMA, Mac-3, and necrotic core areas, and percentage of cells undergoing cell proliferation (Ki67) or apoptosis (CC3) in ATM^+/+/ApoE^−/− or ATM^+/−/ApoE^−/− mice. Right columns: Plaque areas and percentages for ATM^+/+/ApoE^−/− or ATM^+/−/ApoE^−/− mice undergoing ATM^+/+/ApoE^−/− BMT. Data are means±SEM.

^*P<0.05 for ATM^+/− mice vs ATM^+/+ mice, or ATM^+/− vs ATM^+/+ recipients.