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. 2010 Nov 15;191(4):701–710. doi: 10.1083/jcb.201006173

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© 2010 Chapin and Caplan

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — PC1 and PC2 affect multiple signaling pathways. Summary of the effects that PC1 and PC2 exert on signaling pathways. Multiple direct and indirect interactions allow the polycystin proteins to inhibit or stimulate pathways involved in cellular growth and differentiation.