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. Author manuscript; available in PMC: 2010 Nov 17.
Published in final edited form as: Biochem J. 2009 Sep 25;423(2):157–168. doi: 10.1042/BJ20090942

Figure 3. Relationships between HR and NHEJ in mammalian cells.

Figure 3

(A) One of the early ‘choices’ in DSB repair is the extent to which the DNA ends are processed. In classical NHEJ, end resection may be minimal or absent. Should the ends be processed to yield a 3′ overhang, repair can occur through either HR, SSA or MMEJ. (B) Defects in NHEJ skew DSB repair in favour of HR.