Table 2.
Strains killed in the serum bactericidal assay (SBA) by pooled sera from healthy adults who had received three doses of 4CMenB
| Vaccine antigens with relative antigen potency above the positive bactericidal threshold* | No. killed in SBA | Total no. of strains | % (95% CI†) |
| None | 22 | 33 | 67 (48–81) |
| One | |||
| NHBA | 14 | 18 | 78 (52–93) |
| NadA | 5 | 6 | 83 (36–99) |
| fHBP | 16 | 17 | 94 (69–100) |
| Total | 35 | 41 | 85 (70–94) |
| Two | |||
| fHBP and NHBA | 27 | 29 | 93 (76–99) |
| fHBP and PorA | 2 | 2 | 100 (20–100) |
| NHBA and NadA | 3 | 3 | 100 (31–100) |
| Total | 32 | 34 | 94 (79–99) |
| Three | |||
| PorA and fHBP and NHBA | 13 | 13 | 100 (72–100) |
| fHBP and NadA and NHBA | 3 | 3 | 100 (31–100) |
| Total | 16 | 16 | 100 (76–100) |
| Any (one, two, or three) | 83 | 91 | 91 (83–96) |
*Only antigen combinations that apply to one or more strains are included.
†Ninety-five percent CIs were calculated using the prop.test() function, with Yates’ continuity correction, as implemented in the R package, version 2.4.0 (www.r-project.org).