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. 2010 Oct 25;107(45):19444–19448. doi: 10.1073/pnas.1006608107

Fig. 1.

Fig. 1.

Properdin consumption in mice with accelerated AP turnover. (A) Crry-deficient mice. In this and subsequent graphics, detection of properdin in WT, Crry+/−, and Crry SKO mice was by a pull-down assay using protein A-conjugated Sepharose 4B followed by Western blotting of the eluate. C3, fB, and fH were detected by direct Western blots. Properdin has been assayed with similar results in five Crry+/− and 27 Crry SKO mice. (B) CVF-treated mice. Serum was harvested at 30 and 90 min and 7 d following CVF injection. Note that the Ab to mouse C3 primarily recognizes the α-chain and its α2 fragment. Representative of three experiments. m, minute; d, day.