Fig. 3.

Properdin deficiency in mice with a defect in AP activation. (A) Properdin was determined in WT and complement-deficient mice. This experiment is representative of 12 C3^−/−, 9 fB^−/−, 9 fD^−/−, 8 C4^−/−, and 7 C1q^−/− mice. (B) Properdin is normal in B10.WT and B10.C5^−/− mice. (C) Properdin is deficient in Crry^−/−C3^−/− and Crry^−/−fB^−/− mice.