Fig. 2.

Uterine proliferative response to E₂ and IGF-1 in WT and UtEpiαERKO mice. The uterine wet weight increase after (A) 24 h or (B) 3-d (three consecutive days) treatment of vehicle, E₂ in the presence or absence of ICI treatment, and (C) the fluorescent signal of Hoescht 33342 and EdU incorporation/Alexafluor488 staining in the uterine sections from mice treated with vehicle, E₂ (24 h or 3 d), or IGF-1 (24 h). (Scale bar: 20 μm.) Results are mean ± SEM (n = 7). *, and ***p < 0.05 and 0.001, significantly different from vehicle control of the corresponding genotype, respectively. ⁺, p < 0.05 significantly different from E₂-treated WT mice.