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p53312A/A mice are able to partially rescue Mdm4−/− embryonic lethality. (A) Survival of Mdm4−/− embryos relative to the expected Mendelian frequency. (B) WT, Mdm4+/+p53312A/A, Mdm4−/−p53WT, Mdm4−/−p53312A/+, and Mdm4−/−p53312A/A embryos at embryonic day 10.5 (E10.5) and E12.5. No Mdm4−/− embryos with WT p53 were isolated at E12.5. (C) Fold growth of Mdm4−/− MEFs following serial passage.
