Table 3:
Death |
First 6 months
|
Death |
After 6 months
|
|||
Loss to follow-up | Death or lost to follow-up a | Loss to follow-up | Death or lost to follow-up a | |||
Variable | ||||||
CD4 counts | ||||||
≥50 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
< 50 | 1.8 (0.3–10.7) | 2.3 (1.4–3.7) b | 2.3 (1.5–3.7) b | 1.4 (0.1–16.3) | 1.0 (0.4–2.0) | 1.0 (0.5–2.1) |
Active TB | ||||||
No | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
Yes | .... | 1.8 (1–3.6) b | 1.6 (0.8–3.2) | ..... | 2.2 (0.8–6.5) | 1.9 (0.7–5.6) |
Note. Data are adjusted hazard ratio (95% CI). Hazard ratios were estimated for the time-to-event outcomes of death, lost to follow-up and death or lost to follow-up using an extended Cox model allowing for a time-dependent variable (SAS PHREG Procedure). We defined for each variable in the model, a product term with a heavy side function of time (before and after 6 month) based on the pattern of the survival curves. Analyses were adjusted on site, WHO stage, previous HAART. TB, tuberculosis.
We performed sensitivity analysis to estimate to hazard of death in a worst-case scenario where we considered all the losses to follow-up as deaths.
Significant hazard ratio at 5% level of significance.