Figure 2.

Schematic of the reaction network. Model reactions are indicated by bold arrows, the corresponding rate constants (k) or rate functions (ν) are indicated. Note that here complex formation between FIH and ARD proteins is shown explicitly for clarity, however in the model this reaction is assumed at steady state and implicit in the AR-hydroxylation rate function, ν_FA. Also, binding of FIH to hydroxylated ARs is accounted for in the Full Model, but not shown in this schematic. Skeleton Models 1 (SKM1, red shading) and 2 (SKM2, green shading) describe subsystems of the full system. ARD, ankyrin-repeat domain proteins. $k_s^A$, $k_s^H$, synthesis rates of ARDs and HIFα, respectively. $k_d^A$, $k_d^H$, basal degradation rates of ARDs and HIFα, respectively. ν_P, ν_FH and ν_FA, rate functions for HIFα ODD-, HIFα CAD-and ARD protein-hydroxylation, respectively.