Table 2.
Number | Parameter description | Parameter | Values | Source | |
---|---|---|---|---|---|
1 | PHD concentration | 0.2 | estimate | ||
2 | Dissociation constant of PHD/HIFα binding | 1 | [29] | ||
3 | (kcat for ODD-hydroxylation)/(basal HIFα degradation rate constant) | 500 | [31] | ||
4 | FIH concentration | 1 | estimate | ||
5 | Dissociation constant of FIH/HIFα binding | 1 | set to same as 2 | ||
6 | (kcat for HIFα CAD-hydroxylation)/(kcat for HIFα ODD-hydroxylation) | 1 | estimate | ||
7 | (KM of FIH for oxygen)/(KM of PHD for oxygen) | 0.33 | [30] | ||
8 | total concentration of FIH target ARs | 0 - 500 | varied | ||
9 | Dissociation constant of FIH/ARD protein binding (unhydroxylated ARs) | 1 | set to same as 2 | ||
10 | (FIH affinity for hydroxylated)/(FIH affinity for unhydroxylated ARs) | γ | 0 - 0.1 | varied | |
11 | (basal HIFα degradation rate constant)/(AR degradation rate constant) | 1 - 10 | varied | ||
12 | Dissociation constant of HIF/HRE binding | 0.3 | estimate | ||
13 | Oxygen concentration | 0 - 1 | varied |