Table 2.

Dimensionless parameter values used for the Full Model.

Number	Parameter description	Parameter	Values	Source
1	PHD concentration	$${\widehat{P}}_{tot}$$	0.2	estimate
2	Dissociation constant of PHD/HIFα binding	$${\widehat{K}}_D^P$$	1	[29]
3	(kcat for ODD-hydroxylation)/(basal HIFα degradation rate constant)	$${k^{\prime }}_{cat}^P$$	500	[31]
4	FIH concentration	$${\widehat{F}}_{tot}$$	1	estimate
5	Dissociation constant of FIH/HIFα binding	$${\widehat{K}}_D^{FH}$$	1	set to same as 2
6	(kcat for HIFα CAD-hydroxylation)/(kcat for HIFα ODD-hydroxylation)	$$\omega =\frac{K_{cat}^{FH}}{K_{cat}^{FA}}$$	1	estimate
7	(KM of FIH for oxygen)/(KM of PHD for oxygen)	$$\alpha =\frac{K_M^F}{K_M^P}$$	0.33	[30]
8	total concentration of FIH target ARs	$${\widehat{A}}_{tot}$$	0 - 500	varied
9	Dissociation constant of FIH/ARD protein binding (unhydroxylated ARs)	$${\widehat{K}}_D^{FA}$$	1	set to same as 2
10	(FIH affinity for hydroxylated)/(FIH affinity for unhydroxylated ARs)	γ	0 - 0.1	varied
11	(basal HIFα degradation rate constant)/(AR degradation rate constant)	$$\epsilon =\frac{k_d^H}{k_d^A}$$	1 - 10	varied
12	Dissociation constant of HIF/HRE binding	$${\widehat{K}}_D^{HRE}$$	0.3	estimate
13	Oxygen concentration	$${\tilde{O}}_2$$	0 - 1	varied