Table 2.
Unadjusted and Adjusted Odds Ratio (OR) and 95% Confidence Interval (CI) for Placental Abruption in Relation to Maternal History of Headaches and Migraine, Lima, Peru, 2006-2008
| Placental Abruption | ||||||
|---|---|---|---|---|---|---|
| Cases (N = 375) | Controls (N = 368) | |||||
| Exposure Status | n | % | n | % | Unadjusted OR (95% CI) |
1Adjusted OR (95% CI) |
| Lifetime History of Headaches and Migraine (ICHD Criteria) | ||||||
| No | 225 | 60.0 | 259 | 70.4 | ||
| Yes | 150 | 40.0 | 109 | 29.6 | 1.58 (1.17-2.15) | 1.60 (1.16-2.20) |
| Migraine headache | 44 | 11.7 | 23 | 6.3 | 2.20 (1.29-3.76) | 2.14 (1.22-3.75) |
| Tension-type headaches | 51 | 13.6 | 38 | 10.3 | 1.54 (0.98-2.44) | 1.61 (1.01-2.57) |
| Other headaches | 55 | 14.7 | 48 | 13.0 | 1.32 (0.86-2.02) | 1.35 (0.87-2.09) |
| Lifetime History of Migraine with aura(ICHD criteria)2 | ||||||
| No Headaches or Migraine | 225 | 60.0 | 259 | 70.4 | 1.00 (referent) | 1.00 (referent) |
| Migraine without aura | 23 | 6.1 | 12 | 3.3 | 2.21 (1.07-4.53) | 2.11 (1.00-4.45) |
| Migraine with aura | 21 | 5.6 | 11 | 3.0 | 2.20 (1.04-4.66) | 1.59 (0.70-3.62) |
| Onset of Migraine (ICHD criteria)2 | ||||||
| No Headaches or Migraine | 225 | 60.0 | 259 | 70.4 | 1.00 (referent) | 1.00 (referent) |
| Yes, onset during pregnancy | 5 | 1.3 | 2 | 0.5 | 2.88 (0.55-14.98) | 2.63 (0.48-14.44) |
| Yes, onset prior to pregnancy | 39 | 10.4 | 21 | 5.7 | 2.14 (1.22-3.74) | 1.79 (0.98-3.27) |
| Headache or Migraine Onset | ||||||
| No headache | 225 | 60.0 | 259 | 70.4 | 1.00 (referent) | 1.00 (referent) |
| Final month of pregnancy | 5 | 1.3 | 3 | 0.8 | 1.92 (0.45-8.12) | 1.67 (0.39-7.24) |
| First 8 months of pregnancy | 34 | 9.1 | 24 | 6.5 | 1.63 (0.94-2.83) | 1.62 (0.92-2.85) |
| Prior to pregnancy | 111 | 29.6 | 82 | 22.3 | 1.56 (1.11-2.18) | 1.66 (1.16-2.37) |
| History of Physician Diagnosed Migraine | ||||||
| No | 350 | 93.3 | 348 | 94.6 | 1.00 (referent) | 1.00 (referent) |
| Yes | 25 | 6.7 | 20 | 5.4 | 1.24 (0.68-2.28) | 1.13 (0.60-2.12) |
1Adjusted by maternal age, education, smoking status, alcohol consumption, prenatal care utilization and maternal depression status
2Women with non-migrainous headache disorders were deleted from this analysis; column percentages will not sum to 100%