Table 1.
AMFE Comparison between non-conserved and conserved pre-miRNAs from human, mouse, and chicken genomes
| Species | Conservation | AMFE (kcal/mol) | p1 | p2 |
|---|---|---|---|---|
| Human | Sn (132) | 44.1 ± 14.1 | ||
| Sc1 (60) | 45.2 ± 9.98 | 5.4×10-1 | *3.7×10-3 | |
| Sc2 (66) | 44.6 ± 7.06 | 7.8×10-1 | *8.6×10-9 | |
| Sc3 (33) | 44.7 ± 6.36 | 7.5×10-1 | *2.3×10-6 | |
| Mouse | Sn (108) | 41.0 ± 9.79 | ||
| Sc1 (63) | 45.1 ± 7.83 | *5.2×10-3 | *4.5×10-2 | |
| Sc2 (75) | 45.0 ± 6.93 | *2.4×10-3 | *1.4×10-4 | |
| Sc3 (39) | 43.8 ± 5.89 | 5.6×10-2 | *4.8×10-4 | |
| Chickena | Sn (21) | 42.2 ± 14.7 | ||
| Sc2 (40) | 41.6 ± 5.59 | 8.7×10-1 | *3.3×10-7 | |
| Sc3 (19) | 42.3 ± 5.05 | 9.8×10-1 | *3.1×10-5 | |
The number of pre-miRNAs within each set is indicated in brackets behind set name. a Sc1 for chicken was excluded as it contained fewer than five pre-miRNAs. AMFE, the AMFE mean values (± SD). Pair-wise comparisons were performed between non-conserved (Sn) and conserved pre-miRNAs (Sc1, Sc2, and Sc3) from human, mouse, and chicken genomes. p1, P-value of two-sample two-sided t-test (without assuming equal variance) for AMFE means. p2, P-value of two-sample two-sided F-test for AMFE variances. * the P-value is significant at the 0.05 FDR level.